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ONCOGENE PROTEIN P21(RAS)
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DeCS
Descriptor
English
:
Oncogene Protein p21(ras)
Descriptor
Spanish
:
Proteína Oncogénica p21(ras)
Descriptor
Portuguese
:
Proteína Oncogênica p21(ras)
Synonyms
English
:
ras Oncogene Protein p21
p21(v-Ha-ras)
p21(v-Ki-ras)
Tree Number:
D08.811.277.040.330.300.400.500.300
D12.644.360.525.500.300
D12.776.157.325.515.500.300
D12.776.476.525.500.300
D12.776.624.664.520.750.710
D12.776.964.700.750.710
D12.776.964.775.750.710
Definition
English
:
Transforming protein encoded by ras
oncogenes
. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian
cells
. Oncogene protein p21(ras) has been directly implicated in human
neoplasms
, perhaps
accounting
for as much as 15-20% of all human tumors. This enzyme was formerly listed as EC 3.6.1.47.
Indexing Annotation
English
:
coord with specific virus
History Note
English
:
1990
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24815
Unique Identifier:
D015689
Occurrence in VHL
:
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